*Seminar Series: Special IMB Seminar
*Location: QBP Auditorium, Bld 80
*Date: 13/09/2017
*Time: 14.30

Speaker #1 details
*Title of talk: The Nuclear Lamina - a key modulator of Vascular Ageing?
*Speaker's name: Professor Catherine Shanahan
*Speaker's organisation: King's College London
Speaker's city/state/country: UK
Talk Abstract: Ageing is the strongest risk factor for cardiovascular disease and has historically been viewed as unmodifiable. However, emerging evidence from rare genetic conditions that disrupt the functionality of the nuclear lamina, suggests that this scaffolding structure can regulate tissue specific ageing mechanisms. Using vascular calcification as an example of an untreatable but ubiquitous age-related vascular pathology, we have shown that vascular smooth muscle cells acquire specific nuclear lamina defects with age and disease. These defects promote perturbations in mechanical, epigenetic and transcriptional signaling which act to accelerate ageing and calcification, not only in the adult population but also in children. Understanding how these pathological processes are temporally regulated will provide new therapeutic targets to increase cardiovascular 'health span' in the ageing population.
Speaker's bio: Professor Shanahan obtained her BSc(Hons) and PhD in Genetics from the University of Adelaide, Australia. She worked for CSIRO in Sydney, Australia before moving to the University of Cambridge as a post-doc in the Departments of Biochemistry and then Medicine. In 1995 she was appointed as a British Heart Foundation Basic Sciences Lecturer and in 2005 became a British Heart Foundation Senior Fellow in the Department of Medicine, University of Cambridge. In 2007 she took up the position of Professor of Cellular Signalling at King's College London. Professor Shanahan is currently a member of the British Atherosclerosis Society (BAS) and served on its committee from 2001-2004, is a nucleus member of the Atherosclerosis Working Group of the European Cardiac Society and is a member of the British Society of Cardiovascular Research (BSCR) and the North American Vascular Biology Organisation (NAVBO). She is currently on the Editorial Boards of Circulation Research, Arteriosclerosis, Thrombosis and Vascular Biology, Current Cardiology Reviews and Kidney International.

Speaker #2 details
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Other Details:
*Host name: Professor Brandon Wainwright
Host phone number:
*Host email: imbevents@uq.edu.au