*Seminar Series: SCMB Seminar
*Location: AIBN Seminar Room
*Date: 11/07/2017
*Time: 15:00

Speaker #1 details
*Title of talk: Of mice and men: the role of host type I interferon signaling in control of Ebola virus replication.
*Speaker's name: Dr Sonja Best
*Speaker's organisation: Rocky Mountains Laboratories, National Institute of Allergy and Infectious Diseases
Speaker's city/state/country: USA
Talk Abstract: The unprecedented 2013-2016 outbreak of Ebola virus (EBOV) resulted in over 11,300 human deaths. Host resistance to RNA viruses requires RIG-I-like receptor (RLR) signaling through the adaptor protein, mitochondrial antiviral signaling protein (MAVS) to induce production of type I interferon (IFN). However, the role of RLR-MAVS in orchestrating anti-EBOV responses in vivo is not completely understood. Wild-type EBOV (WT-EBOV) is not lethal in immunocompetent mice, although virus adaptation to mice is associated with mutations that facilitate replication and increase virulence. The mechanisms by which these mutations confer host-specific virulence is also not clear. This seminar will discuss our two areas of research regarding EBOV interactions with the host IFN response: 1) the systems biology of MAVS signaling in mice that has revealed tissue-specific MAVS-dependent transcriptional pathways associated with host resistance to EBOV, and 2) examination of specific human IFN-stimulated genes (ISGs) that interact with EBOV and confer host specific-resistance to EBOV infection.
Speaker's bio: Dr. Best received her Ph.D. from the Australian National University where she studied poxvirus pathogenesis. She conducted postdoctoral research at Rocky Mountain Laboratories (RML) campus on the role of apoptosis in the replication of parvoviruses. She stayed at RML as a Staff Scientist to investigate virus-host interactions involved in evasion of host innate immunity by flaviviruses. In 2009, Dr. Best established an independent laboratory to expand her studies on the induction and evasion of innate immunity by highly pathogenic RNA viruses utilizing the newly built BSL4 laboratories at RML. Dr. Best is on the Editorial Board for several journals including Science Translational Medicine, Journal of Virology and Journal of Biological Chemistry, and was awarded a Presidential Early Career Award for Scientists and Engineers (PECASE) by President Obama for her work.

Speaker #2 details
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Other Details: If you would like to meet with the speaker, please contact Alex Khromykh (alexander.khromykh@uq.edu.au)
*Host name: Alexander Khromykh
Host phone number:
*Host email: alexander.khromykh@uq.edu.au