*Seminar Series: SCMB Molecular Bioscience Seminar
*Location: AIBN Seminar Room
*Date: 05/07/2017
*Time: 12:00

Speaker #1 details
*Title of talk: Structural characterisation of bioactive disulfide-rich peptides and their interactions with lipid membranes and ion channels in solution
*Speaker's name: A. Prof Mehdi Mobli
*Speaker's organisation: Centre for Advanced Imaging
Speaker's city/state/country:
Talk Abstract: Disulfide-rich peptides including hormones, toxins and antimicrobial peptides, are short polypeptide chains (peptides) that fold into defined three-dimensional structures. They are secreted molecules that have naturally evolved high potency and selectivity, to regulate biological processes while remaining stable in the harsh extracellular milieu. These peptides owe their remarkable stability to formation of multiple, covalent, disulfide bonds between the side chains of different cysteine residues that act to "tie" the molecule into well-defined "scaffolds". I will present work on (1) the production and isotope labeling of disulfide rich peptides, including the production of segmentally labelled two domain peptides, (2) application of advanced NMR methods in structural characterisation of these peptides and finally (3) the interaction of these peptides with both their receptors and to membrane bilayers. Looking ahead I will discuss our approach to targeting ion-channels for drug discovery through fragment screening.
Speaker's bio: Mehdi Mobli is a Group Leader at the UQ Centre for Advanced Imaging. He is fascinated by peptide and protein structures, and is curious to find out how such molecules go about their daily life (dynamics) and perform their function in solution. He is particularly interested in disulfide rich peptides, in particular those that inhibit ion channels. He has developed advanced NMR based approaches for structural studies of proteins and for investigating peptide-channel interactions. He was award an ARC Future Fellowship in 2011 and the Sir Paul Callaghan Medal in 2013 by the Australia and New Zealand Society for Magnetic Resonance (ANZMAG).

Speaker #2 details
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Other Details:
*Host name: Kate Stacey
Host phone number:
*Host email: Katryn.Stacey@uq.edu.au