*Seminar Series: SCMB Chemistry Seminar
*Location: AIBN Seminar Room
*Date: 19/06/2017
*Time: 13:00

Speaker #1 details
*Title of talk: Twisting tails and pKa pathways in key biosynthetic enzymes
*Speaker's name: Prof. Emily Parker
*Speaker's organisation: Victoria University of Wellington
Speaker's city/state/country: New Zealand
Website: http://www.canterbury.ac.nz/science/schools-and-departments/chem/people/parker.shtml
Talk Abstract: Protein conformational changes and dynamics play critical roles in delivering enzyme function. We have examined the roles of conformational adjustments in delivering both catalysis and allosteric functionality to enzymes that play key roles in amino acid biosynthesis.

Our studies examine both the active site and allosteric regulation of ATP phosphoribosyltransferase and 3-deoxy-D-arabino heptulosonate 7-phosphate synthase, which are both key enzymes in the biosynthesis of amino acids. Both these enzyme are critical for bacterial function and have been identified as targets for antimicrobial drug design. We have examined both catalytic and allosteric mechanisms using computational, kinetic and structural techniques.

1. Cross PJ, Allison TM, Dobson RCJ, Jameson GB, Parker EJ. Engineering allosteric control to an unregulated enzyme by transfer of a regulatory domain. Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 2111-2116.
2. Lang EJ, Heyes LC, Jameson GB, Parker EJ. Calculated pKa variations expose dynamic allosteric communication networks. J. Am. Chem. Soc. 2016, 138, 2036-45.
3. Blackmore NJ, Nazmi AR, Hutton RD, Webby MN, Baker EN, Jameson GB, Parker EJ. Complex formation between two biosynthetic enzymes modifies the allosteric regulatory properties of both an example of molecular symbiosis. J. Biol. Chem. 2015, 290, 18187-18198.
4. Nazmi AR, Lang EJM, Bai Y, Allison TM, Othman MH, Panjikar S, Arcus VL, Parker EJ. Interdomain Conformational Changes Provide Allosteric Regulation En Route To Chorismate. J. Biol. Chem. 2016, 291, 21836-21847.
5. Mittelstädt G, Moggré G-J, Panjikar S, Nazmi AR, Parker EJ. Campylobacter jejuni adenosine triphosphate phosphoribosyltransferase is an active hexamer which is allosterically controlled by the twisting of a regulatory tail. Protein Sci. 2016, 25, 1492-1506.
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Speaker #2 details
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Other Details: Anybody wishing to meet with Prof. Parker may contact Elizabeth Krenske.
*Host name: Elizabeth Krenske
Host phone number:
*Host email: e.krenske@uq.edu.au