*Seminar Series: QBI Neuroscience Seminar
*Location: QBI Auditorium
*Date: 13/06/2017
*Time: 12.45

Speaker #1 details
*Title of talk: The midbrain periaqueductal gray: A novel circuit for treatment of intractable neurogenic autonomic disease via neuromodulation
*Speaker's name: Dr Hari Subramanian
*Speaker's organisation: Queensland Brain Institute,The University of Queensland
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Talk Abstract: The autonomic nervous system (ANS) regulates respiration, vocalization, blood pressure and heart rate, micturition, nociception, sexual and gastrointestinal function and the co-ordination of their physiological responses to emotional behavior. Diseases of the ANS include breathing and vocalization disorders, hypertension, chronic pain and urinary incontinence. These manifest either due to neurogenic dysfunction of autonomic control circuits and/or accompany psychiatric and emotional disorders.\r\n\r\nDeep Brain Stimulation (DBS) neuromodulation is seen as an emerging novel treatment option for a range of primary dysautonomias, autonomic dysreflexia and for conditions reflecting catastrophic autonomic dysfunction such as in the cases of sudden unexpected death in epilepsy. The scope of DBS application is vast because autonomic diseases are most often severe, pharmaco-refractory, life threatening or life-impairing.\r\n\r\nAutonomic functions are controlled via complex interaction between brainstem neural circuits and peripheral feedback pathways. Together they constitute the central autonomic network (CAN).\r\n\r\nWithin the CAN the midbrain periaqueductal gray (PAG) situated at the rostral end of the brainstem could be a one \'stop shop\' for treatment of autonomic disease via DBS neuromodulation.\r\n\r\nThis seminar will examine how; 1) the PAG functions as the critical relay circuit of the forebrain integrating emotion and bodily responses, 2) whether there exists autonomic topography within the PAG, i.e. segregation of neural circuits specific to single autonomic function, 3) how PAG dysfunction triggers respiratory, vocalization cardiovascular and urinary disease states 4) how selective neuromodulation of PAG circuits for therapeutic target of specific autonomic disease can be achieved. Further the seminar would examine autonomic disease animal models and design/implantation aspects of neural prosthesis in the brainstem for neuromodulation therapy advancement.
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Speaker #2 details
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Other Details:
*Host name: Deirdre Wilson
Host phone number:
*Host email: d.wilson@qbi.uq.edu.au