*Seminar Series: Chemistry and Structural Biology Division Seminar
*Location: AIBN seminar room (IMB/AIBN joined seminar)
*Date: 15/06/2017
*Time: 12:30

Speaker #1 details
*Title of talk: A orthogonal cofactor for biocatalysis
*Speaker's name: Assoc. Prof. Colin Jackson
*Speaker's organisation: The Australian National University
Speaker's city/state/country: Canberra
Website: http://chemistry.anu.edu.au/people/colin-jackson
Talk Abstract: Enzymes are remarkable catalysts, with application in industry, medicine and the environment. Many of the more energetically demanding reactions catalysed by enzymes require the use of cofactors than contribute additional chemical reactivity not available in the 20 proteinogenic amino acids. However, these same cofactors are used by hundreds of cellular enzymes required for growth and survival of the various organisms in which engineered or designer enzymes might be over-expressed, limiting cofactor availability or growth.

In this talk I will discuss the relatively rare F420 cofactor from Archaea and actinobacteria and our work expressing it in Escherichia coli to create a bioorthogonal cofactor that can be used exclusively for biocatalysis with engineered/overexpressed enzymes. I will also discuss some of the interesting chemical transformations that are possible with this cofactor (and the enzymes that utilise it).
Speaker's bio: Dr Colin Jackson has held research positions at the Commonwealth Scientific and Industrial Research Organisation (CSIRO) and was a visiting research fellow at the Weizmann Institute of Science (Rehovot, Israel) and a Marie Curie Research Fellow at the Institut de Biologie Structurale (Grenoble, France), before his appointment as a Senior Lecturer at the Research School of Chemistry.

Speaker #2 details
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Other Details:
*Host name: Dr Jason Whitfield
Host phone number: 07 3346 2172
*Host email: j.whitfield@imb.uq.edu.au