*Seminar Series: IMB Seminar Series
*Location: QBP Auditorium, Bld 80
*Date: 02/06/2017
*Time: 12:30

Speaker #1 details
*Title of talk: Liquid Biopsies: Monitoring the Cancer Genome in Blood
*Speaker's name: Associate Professor Sarah-Jane Dawson
*Speaker's organisation: Peter MacCallum Cancer Centre
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Talk Abstract: Cell-free circulating DNA containing tumor-specific sequences can be identified in the plasma of cancer patients, providing a liquid biopsy alternative to tissue biopsies for monitoring cancer genetic changes over time. Circulating tumor DNA (ctDNA) analysis can allow real-time monitoring of tumor dynamics and treatment response from a simple blood test that is safe, reliable and easy to perform at regular intervals during therapy. Serial analysis of ctDNA provides a unique opportunity to study the evolving genomic landscape of a cancer during therapy, identify the early emergence of treatment resistance and guide targeted therapeutic decisions. A summary of current approaches for ctDNA analysis will be presented, together with an overview of clinical applications for the use of liquid biopsies in cancer management.
Speaker's bio: Associate Professor Sarah-Jane Dawson is a clinician-scientist. She obtained her medical degree from the University of Melbourne, and trained as an oncologist in Melbourne, Australia. She completed her PhD at the University of Cambridge, UK. Following postdoctoral studies at the Cambridge Research Institute, she returned to Melbourne in 2014 to head the newly formed Molecular Biomarkers and Translational Genomics Laboratory at the Peter MacCallum Cancer Centre. Her current research interests lie in understanding the genomic evolution of cancer and using this information to develop noninvasive molecular biomarkers for clinical application, including early detection, risk stratification and disease monitoring. The major focus of her research is the development of blood-based biomarkers ('liquid biopsies') through the use of circulating tumour DNA in both solid and haematological malignancies.

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Other Details:
*Host name: Professor Alpha Yap
Host phone number:
*Host email: imbevents@uq.edu.au