*Seminar Series: IMB Seminar Series
*Location: QBP Auditorium, Bld 80
*Date: 12/05/2017
*Time: 12:30

Speaker #1 details
*Title of talk: Modulating Inflammation via Macrophage Membrane Domains & TLR Signaling Pathways
*Speaker's name: Professor Jennifer Stow
*Speaker's organisation: Institute for Molecular Bioscience, UQ
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Talk Abstract: The immune activation of macrophages via Toll-like receptors (TLR) triggers powerful pro-inflammatory cytokine responses, followed by inflammation-resolving, anti-inflammatory responses. An imbalance in this programming accompanies and contributes to acute and chronic inflammation in disease. Complex networks of regulators modulate TLR-induced signaling pathways and transcriptional programs to bias cytokine production. Our research has uncovered novel roles for Rab GTPases, signaling adaptors, phospholipid kinases and cross-talk receptors that participate in biasing macrophage outputs and functions. TLR signaling is also spatiotemporally controlled, and using advanced live cell imaging we can reveal the dynamic cell surface structures and compartments that host signaling regulators and traffic receptors. This research is piecing together a landscape of druggable targets for controlling inflammation.
Speaker's bio: Professor Jennifer L. Stow
After graduating with a PhD from Monash University, Jenny moved to the Department of Cell Biology at Yale University Medical School (New Haven, USA) as a Fogarty International postdoctoral fellow in the laboratory of Professor Marilyn Farquhar. Her first faculty appointment followed as an Assistant Professor in the Renal Unit, Departments of Medicine and Pathology, at Massachusetts General Hospital/Harvard Medical School (Boston). In late 1994 she relocated her group to CMCB, now IMB, at The University of Queensland, Australia, as a Wellcome Trust Senior International Medical Research Fellow, then as an NHMRC Research Fellow. She is currently appointed as a Group Leader, Protein Trafficking and Inflammation, and as the Deputy Director (Research) at the Institute for Molecular Bioscience (IMB).

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Other Details:
*Host name: Associate Professor Kate Schroder
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*Host email: imbevents@uq.edu.au