*Seminar Series: SCMB Chemistry Seminar
*Location: AIBN Seminar Room
*Date: 09/05/2017
*Time: 13:00

Speaker #1 details
*Title of talk: Polar Lipocompatible Units in Drug Discovery
*Speaker's name: Prof. Klaus Muller
*Speaker's organisation: ETH Zurich
Speaker's city/state/country: Switzerland
Talk Abstract: t: Polar groups of a molecule are typically assumed to remain exposed to the polar (water) environment upon binding of the molecule to a hydrophobic pocket of the target protein. While this is true in most of the cases, there are nevertheless a number of polar groups that are equally well accommodated within lipophilic protein pockets. These 'polar lipocompatible' groups play an important role in the design of protein-targeted molecules. Some important representatives are (partially) fluorinated alkyl or alkoxy groups, sulfone-containing moieties, and oxetane units. They share interesting aspects of polarity, polarization, and conformational control, which render them useful for rational modulation of compound properties.
Speaker's bio: Klaus Müller has been Extraordinary Professor at the University of Basel since 1991. Prior to his retirement in 2009 he occupied leading positions at F. Hoffmann-La Roche AG, among them as Head of ‚Pharma New Technologies' and of ‚Science and Technology Relations' for the development of innovative technologies and scientific collaborations with external groups. He was Secretary-General and Board Member of the Roche Research Foundation until its conclusion in 2008. After his retirement in early 2009 until the end of 2015, he acted as full-time Science & Chemistry Consultant with Roche, engaging in research on building block design in Medicinal Chemistry and managing the Roche Postdoc Fellowship Program. Since January 2016 he is Senior Research Associate at the Laboratory for Organic Chemistry, ETH Zürich, integrated in the research Group of Prof. Erick M. Carreira, where he continues his research in the design and exploration of novel building blocks for Medicinal Chemistry. Educated as Organic Chemist at ETH Zurich, he got his PhD in 1970 (with Prof. Albert Eschenmoser), undertook a 1-year postdoctoral stay in the US in physical-organic chemistry (with Prof. Gerhard L. Closs, U Chicago), and was then Lecturer at Harvard University, before returning to ETHZ in late 1974. He habilitated in 1977 and remained there as junior staff member before joining Roche in 1982 to develop computer-assisted molecular modeling and implementing structural biology and bioinformatics. He fostered the development of novel compound storage and ultra-HT screening systems, helped building a comprehensive miniaturized and parallelized platform for fast compound property analytics, and guided the development of a first chemistry-biology information management system. Structure- and property-based molecular design, both conceptual and experimental, has been a major area of interest where he is still active today.

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Other Details: Anybody wishing to meet with this speaker may contact Elizabeth Krenske.
*Host name: Elizabeth Krenske
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*Host email: e.krenske@uq.edu.au