*Seminar Series: Chemistry Seminar
*Location: AIBN Seminar Room
*Date: 24/04/2017
*Time: 13:00

Speaker #1 details
*Title of talk: Improving drug delivery to heterogeneous breast tumours
*Speaker's name: Dr Kara Perrow
*Speaker's organisation: University of Wollongong
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Website: https://scholars.uow.edu.au/display/kara_vine
Talk Abstract: Cancer is characterised by intertumoural and intratumoural heterogeneity. Molecular targeting of a single cancer biomarker in therapy often leads to patient relapse due to the expansion of remaining target negative cells. Liposomes have emerged as a useful drug delivery system to reduce systemic toxicity of chemotherapeutics, and dual functionalised liposomes offer increased active targeting of multiple tumour cell populations and therefore the potential to increase efficacy by eradicating a greater number of cancer cells within a heterogeneous population. Recent research by our group and others has identified a population of cells within the HER2 positive breast cancer subtype that concomitantly express the urokinase plasminogen activator receptor (uPAR), a key facilitator of metastasis. We propose that this uPAR positive subtype may be partially responsible for the failure of HER2 targeted treatment strategies and hypothesize that targeting both uPAR and HER2 on cancer cells may provide a means to overcome therapeutic resistance. Despite the longstanding existence of liposome technology, there have been no functionalised liposome formulations approved for clinical use. This lack of translation may be due in part to the lack of molecular tools available for the robust quantification of protein on the surface of functionalised liposomes. Here we quantify two proteins targeting uPAR and HER2 attached to the surface of small unilamellar liposomes using single molecule fluorescence microscopy techniques in order to develop next gen targeted cancer therapies with the aim of overcoming intratumoural heterogeneity.
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Other Details: Anybody wishing to meet with Dr Perrow may contact Elizabeth Krenske
*Host name: Elizabeth Krenske
Host phone number:
*Host email: e.krenske@uq.edu.au