*Seminar Series: SCMB Seminar
*Location: AIBN seminar room (Building 75)
*Date: 23/03/2017
*Time: 13:00

Speaker #1 details
*Title of talk: Ferrets as a model of disease for BSL4 pathogens
*Speaker's name: Glenn Marsh
*Speaker's organisation: CSIRO, Geelong Victoria
Speaker's city/state/country:
Talk Abstract: The domestic ferret (Mustela putorius furo) have long history of use as an animal model for the study of infectious diseases, human reproductive biology and physiology and non-infectious diseases such as various cancers and cystic fibrosis. Use of ferrets for infectious disease research is facilitated by the complex behaviours they display and their interactions with cage mates and handlers. At the Australian Animal Health Laboratory, ferrets have been routinely used as an animal model for several different viruses including influenza viruses and the highly pathogenic paramyxoviruses, Hendra and Nipah viruses. Based on this experience working with ferrets at biosafety level 4, we have established ferret models of various filoviruses. Ferrets readily become infected with low doses of virus accompanied by the induction of fulminating disease consistent with that observed in humans and in non-human primate infection models. We show that ferrets develop such a disease following exposure to wild-type variants of virus, negating the need for multiple passages to adapt the virus to the model and supporting its biological relevance to clinical scenarios.
Speaker's bio: Glenn Marsh is a Senior Research Scientist and Team Leader for Dangerous Pathogens in CSIRO. His research interests include development of animal models for high consequence viruses and using molecular tools to identify virulence determinants. Glenn's recent work has lead to the development of a ferret model of filovirus disease, which is the first small, non-primate model that can be infected with wild-type viruses, facilitating countermeasure testing.

Speaker #2 details
*Title of talk:
*Speaker's name:
*Speaker's organisation:
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Talk Abstract:
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Other Details: If you would like to meet with the speaker, please contact Natalie Schmidt n.schmidt@uq.edu.au
*Host name: Kate Stacey
Host phone number:
*Host email: mbsseminars@scmb.uq.edu.au