Seminars | This Week

SPECIAL SEMINAR: Australasian Society for Immunology Visiting Speaker Program

Date/Time: Wednesday 21st February 2018 12:00

Location: Level 3 Large Seminar Room (3.142) QBP

Title of talk: Following the speck: pattern recognition receptors in bacterial infections
Speaker's name: Prof Clare Bryant
Speaker's organisation: University of Cambridge

Host name: Prof Matt Sweet
Host email: m.sweet@imb.uq.edu.au

Seminars | This Week

Queensland Genomics Health Alliance Seminar Series

Date/Time: Friday 23rd February 2018 10:00

Location: Lecture Theatre, UQ Oral Health Centre, 288, Herston Road, Herston

Title of talk: Clinical implementation programs of the National Human Genome Research Institute
Speaker's name: Dr Teri Manolio
Speaker's organisation: Director, Division of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health
Talk abstract: Dr Manolio is based in Bethesda, Maryland and directs the National Human Genome Research Institute's (NHGRI) Division of Genomic Medicine, where she leads programs to develop and
implement genomic applications in clinical care.

She moved to NHGRI in 2005 to lead efforts in applying genomic technologies to population research, including the Electronic Medical Records and Genetics (eMERGE) Network, the NHGRI Genome-Wide Association Catalog, the Implementing Genomics in Practice (IGNITE) Network, and the Clinical Genome (ClinGen) Resource.

She continues to practice and teach internal medicine at the Walter Reed National Military Medical Center and the Uniformed Services University of the Health Sciences.

She has research interests in genome-wide association studies of complex diseases, ethnic differences in disease risk, and incorporating genomic findings into clinical care.

Dr Manolio will be visiting Brisbane briefly and we are delighted to have the opportunity to host this seminar with her. We hope that you are able to join us as she shares her experiences of
implementing genomics into healthcare.

Host name: Queensland Genomics Health Alliance
Host phone number: 3443 1080
Host email: communications@qgha.org

Seminars | This Week

Centre for Superbug Solutions Seminar

Date/Time: Monday 26th February 2018 10:00

Location: Large Seminar Room (#3.142), Level 3, Queensland Bioscience Precinct, UQ St. Lucia

Title of talk: Discovery and development of an antimicrobial tetrapeptide with anti-MRSA activity
Speaker's name: Brian Chia, Ph.D.
Speaker's organisation: Experimental Therapeutics Centre - Agency for Science, Technology and Research (ASTAR)
Talk abstract: The emergence of drug-resistant bacteria and the lack of new antibiotics entering the market is a major worldwide concern. Antimicrobial peptides are deemed plausible drug candidates as they target and disrupt bacteria cell membranes, causing death by cell lysis. However, their instability towards plasma proteases and perceived high manufacturing cost limit their potential for drug development. A plausible solution is to identify and develop very short linear peptides as topical agents for treating skin infections.

In this seminar, I shall describe the serendipitous discovery of a tetrapeptide with bactericidal activity against methicillin-resistant S. aureus (MRSA) and the current research effort at the Experimental Therapeutics Centre in Singapore to further its development into a topical antibacterial drug.

Host name: Centre for Superbug Solutions
Host phone number: 62045
Host email: a.pratt2@uq.edu.au

Seminars | This Week

Cell Biology Forum

Date/Time: Wednesday 21st February 2018 09:00

Location: Large Seminar Room

Title of talk: New insights into caveola biogenesis and function
Speaker's name: Dr. Michele Bastiani
Speaker's organisation: IMB, UQ (Parton Lab)

Host name: Dr. Rajesh Ghai and Dr. Melanie Shakespear
Host email: m.shakespear@imb.uq.edu.au

Seminars | This Week

QBI Neuroscience Seminar

Date/Time: Wednesday 21st February 2018 11:00

Location: QBI, Level 7 Auditorium

Title of talk: "NMDA Receptors in the Neural Circuit Underlying Fear Learning"
Speaker's name: Shanzhi Yan
Speaker's organisation: Queensland Brain Institute, The University of Queensland
Talk abstract: N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation is believed to be involved in many forms of learning and memory. In the Hebbian model of fear conditioning, NMDA receptors in the emotional processing circuit, especially in the basolateral amygdala (BLA), are considered as coincidence detectors that transform correlated conditioned and unconditioned stimuli into synaptic plasticity and long-term memory. However, it is unclear whether NMDA receptors are functional in the absence of correlated signal inputs. In the current project, we investigate the involvement of NMDA receptors in signal transmission in the BLA, as well as the storage of acquired associative memory in the emotional processing brain circuit. To investigate the role of NMDA receptors in signal transmission, we performed single unit recording in the BLA and recorded neural activity as well as acoustic responsivity before and after systemic injection of NMDA receptor antagonist (7)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP). Auditory stimulation triggered both excitatory and inhibitory responses in different subgroups of BLA neurons. CPP injection induced a shift in the balance between auditory stimulation-induced excitation and inhibition of BLA neuron in the inhibitory direction. Unit recording results also revealed that pyramidal cells in the LA excitatory recruit interneurons with the same tuning during tone presentations, and that inactivation of NMDA receptors impaired the pyramidal cells mediated recruitment of interneurons in the LA. To investigate the role of NMDA receptors in the formation of discriminative memory, rats received systemic CPP injection immediately after a discriminative auditory fear conditioning training. Inactivation of NMDA receptors after memory acquisition interfered with the consolidation and storage of both fear and safety memories. Intracerebral infusion of CPP directly into a series of brain regions after training showed that fear and safety memories were processed separately in different brain areas. It was likely that in addition to the BLA, fear and safety memories were also stored in the auditory cortical area and the prelimbic cortex, respectively. Together, our results suggested that in the absence of correlated extrinsic signals, NMDA receptors are still functional in processing intrinsic neural activities.

Host name: Deirdre Wilson
Host email: d.wilson5@uq.edu.au