Seminars | This Week

IMB Seminar Series

Date/Time: Friday 18th August 2017 12:30

Location: QBP Auditorium, Bld 80

Title of talk: Mitochondrial herniation and mtDNA release during cell death
Speaker's name: Professor Benjamin Kile
Speaker's organisation: Monash University
Talk abstract: Mitochondrial apoptosis is mediated by BAK and BAX, two proteins that oligomerise in the mitochondrial outer-membrane to induce permeabilization, leading to cytochrome-c efflux and activation of apoptotic caspases. Recent evidence indicates that, in the absence of active caspases, mitochondrial (mt) DNA triggers the innate immune cGAS/STING pathway, causing dying cells to secrete type I interferon. How cGAS gains access to mtDNA remains unclear, particularly since BAK/BAX are not thought to permeabilize the organelle's inner membrane. Using live-cell lattice light-sheet, 3D-structured illuminated and immunogold electron microscopy, we have now shown that BAK/BAX activation leads to mitochondrial inner-membrane herniation and release of mtDNA.

Host name: Associate Professor Ben Hogan
Host email: imbevents@uq.edu.au

Seminars | This Week

IMB Seminar Series

Date/Time: Friday 25th August 2017 12:30

Location: QBP Auditorium, Bld 80

Title of talk: Genetic variation in the complement factor h-related protein 3 gene controls factor H blood levels and determines susceptibility to meningococcal disease
Speaker's name: Dr Sonia Davila
Speaker's organisation: SingHealth Duke-NUS Institute of Precision Medicine (PRISM).
Talk abstract: Genetic variants within complement factor H (CFH) and the five complement factor H-related (CFHR) genes have been associated with susceptibility to a range of human diseases. Factor H (FH) acts as a negative regulator of the alternative complement activation pathway and its circulating plasma levels, mainly secreted by the liver, have been associated with susceptibility to infectious and autoimmune diseases. We have characterized the extremely complex CFH-CFHR1-5 gene interval and fine-mapped the association signal of susceptibility to meningococcal disease. Functional studies demonstrated that the lead SNP in CFHR3 lies in a liver-specific regulatory region that has been shown to loop and interact with CFH at the genomic level. Our data demonstrate that FH is the complement protein associated with meningococcal disease susceptibility and that its expression levels are controlled through a cis-regulatory element located in intron 1 of CFHR3 providing a molecular mechanism relevant to complement dysregulation related diseases.

Host name: Associate Professor Lachlan Coin
Host email: imbevents@uq.edu.au

Seminars | This Week

SBMS Seminar Series

Date/Time: Monday 21st August 2017 13:00

Location: QBI Auditorium, Level 7

Title of talk: A thalamic circuit for directional escape
Speaker's name: Dr Lucy Heap
Speaker's organisation: SBMS, UQ

Host name: Assoc. Professor Ethan Scott
Host phone number: 07 3346 9471
Host email: ethan.scott@uq.edu.au

Seminars | This Week

IMB Special Cell Biology Seminar

Date/Time: Thursday 17th August 2017 14:00

Location: Large Seminar Room (3.142), Level 3 Qld Bioscience Precinct Building 80, St Lucia

Title of talk: Lectin-driven and glycosphingolipid-dependent construction of endocytic pits
Speaker's name: Prof. Ludger Johannes
Speaker's organisation: Curie Institute
Talk abstract: Several endocytic processes do not require the activity of clathrin, and it has been a major question in membrane biology to know how the plasma membrane is bent and cargo proteins are sorted in these cases. Our previous studies have allowed us to propose a novel hypothesis, termed GL-Lect hypothesis: nanodomain construction by GlycosphingoLipid-binding cellular or pathological Lectins induces membrane curvature changes and drives the formation of endocytic pits for the cellular uptake of glycosylated membrane proteins with critical roles in cell migration (CD44, alpha5beta1 integrin…), of pathogens (polyoma viruses, norovirus) or pathogenic factors (Shiga and cholera toxins). We are now analyzing how cortical actin dynamics contributes to the clustering of glycosphingolipid-lectin complexes on active membranes, thereby facilitating the
nucleation of endocytic tubules exploiting fluctuation forces that had not been linked before to endocytosis. Furthermore, we are identifying mechanisms by which the GL-Lect mechanism is acutely controlled at the plasma membrane. Finally, we study how GL-Lect domain construction at the plasma membrane programs the intracellular distribution of cargo molecules, notably via the retrograde transport route.

Host name: Prof Rob Parton
Host email: r.parton@imb.uq.edu.au

Seminars | This Week

QIMR Berghofer - FACULTY SEMINAR

Date/Time: Thursday 17th August 2017 13:00

Location: Auditorium, Level 6, Bancroft

Title of talk: Which modifiable risk factors actually cause cancer?
Speaker's name: Associate Professor Stuart MacGregor
Speaker's organisation: Statistical Genetics
Talk abstract: Find out more via website or poster

Other Details: For more information on all seminars visit upcoming events on the intranet or email events@qimrberghofer.edu.au.

Host name: QIMR Berghofer
Host email: events@qimrberghofer.edu.au

Seminars | This Week

QIMR Berghofer - EARLY CAREER RESEARCHER SEMINAR SERIES

Date/Time: Friday 18th August 2017 16:00

Location: Auditorium, Level 3, Central

Title of talk: TBC
Speaker's name: Dr Kim Lowry
Speaker's organisation: QUT

Other Details: For more information on all seminars visit upcoming events on the intranet or email events@qimrberghofer.edu.au.

Host name: QIMR Berghofer
Host email: events@qimrberghofer.edu.au

Seminars | This Week

QIMR Berghofer - OUR RESEARCH

Date/Time: Friday 25th August 2017 16:00

Location: Auditorium, Level 3, Central

Title of talk: Understanding the Human Brain
Speaker's name: Dr Guy Barry
Speaker's organisation: Neurogenomics
Talk abstract: Find out more via intranet

Other Details: For more information on all seminars visit upcoming events on the intranet or email events@qimrberghofer.edu.au

Host name: QIMR Berghofer
Host email: events@qimrberghofer.edu.au

Seminars | This Week

Bioinformatics and immunologic strategies for the development of vaccines against bovine babesiosis

Date/Time: Thursday 24th August 2017 12:00

Location: Room: Small Seminar Room, Level 3 Qld Bioscience Precinct Building 80, St Lucia

Title of talk: Bioinformatics and immunologic strategies for the development of vaccines against bovine babesiosis
Speaker's name: Professor Juan Mosqueda
Speaker's organisation: Autonomous University of Queretaro in Mexico
Talk abstract: Bovine babesiosis is a tick-borne disease caused by the protozoan parasites of the genus Babesia. Babesia bigemina is one of the causative agents of this disease in temperate regions of the world, including the Americas, where the strains are more virulent than in other parts of the world. It has been shown that a Th1 response correlates with protection in infected cattle. Immunodominant antigens of B. bigemina are highly variable, however conserved, subdominant epitopes are present and are targets for a successful vaccine. In the first part of the presentation, I will talk about the research we have done to identify vaccine candidates that induce protective immune responses using B. bigemina as a model.

Sexual reproduction, a process involving recognition and fusion of two cells, is highly conserved among different taxa. In their host vector, Babesia parasites undergo sexual reproduction, therefore the development of sexual stages and the subsequent formation of the zygote are essential for the parasite to invade the intestinal cells of the vector tick and continue its life cycle. In this part of the talk I will discuss our research focused on the identification of proteins involved in Babesia sexual reproduction as targets for transmission blocking vaccines.

Other Details: Can't make it? This seminar will be live streamed here. You can also participate in the Q&A either on Twitter by using #QAAFILIVE, or email Seminar Coordinator Hannah Hardy.

Host name: Ala Tabor
Host email: a.lewtabor@uq.edu.au

Seminars | This Week

QBI Neuroscience Seminar

Date/Time: Wednesday 23rd August 2017 11:00

Location: Level 7 Auditorium

Title of talk: The role of mitochondrial dysfunction in neurodegenerative diseases
Speaker's name: Professor Aleksandra Filipovska
Speaker's organisation: Laboratory Head, Mitochondrial Medicine and Biology Harry Perkins Institue of Medical Research Perth,
Talk abstract: The size and organization of the animal mitochondrial genome has been reduced and compacted significantly since its endosymbiosis from an α-proteobacterial ancestor. This compaction has necessitated the evolution of unique mechanisms to facilitate rapid changes in gene expression in response to the changing energy demands of the cell. The mitochondrial transcriptome encodes proteins that are subunits of the respiratory chain, responsible for most of the energy production required by cells. Consequently the coordinated regulation of the mitochondrial transcriptome by the nucleus is of particular importance for the maintenance of cell health and energy metabolism, particularly in high energy demand organs such as the brain and heart. We have been investigating the unusual features of mitochondrial RNAs and the RNA-binding proteins that control their production, maturation, translation and stabilization to understand the regulation of mitochondrial gene expression and its contribution to health and disease. I will highlight the devastating consequences of dysregulated mitochondrial gene expression in different models of disease in mice and humans caused by genetic disruption of RNA-binding proteins. Mouse models of disease have enabled us to understand the in vivo role of fundamental processes that regulate mitochondrial RNA metabolism and the pathogenesis of diseases caused by impaired gene expression that cause neurodegeneration.

Other Details: Your attendance at these seminars is both welcomed and encouraged.

For a list of upcoming seminars at QBI, go to
http://www.qbi.uq.edu.au/neuroscience-seminars

Host name: charmaine Palva
Host email: neuroseminars@qbi.uq.edu.au