Seminars | This Week

IMB Seminar Series

Date/Time: Friday 29th September 2017 12.30

Location: QBP Auditorium, Bld 80

Title of talk: Cryo-EM structural studies of Mammalian Mitochondrial Respiratory Supercomplexes
Speaker's name: Dr James Letts
Speaker's organisation: Institute of Science and Technology, Austria
Talk abstract: Mitochondrial electron transport chain complexes I, III and IV are organized into supercomplexes responsible for carrying out cellular respiration. Using electron cryo-microscopy, three architectures of mammalian (sheep) supercomplexes were determined. Distinct arrangements of supercomplex I+III2+IV (the respirasome)—a major \'tight\' form and a minor \'loose\' form (resolved at the resolution of 5.8 Å and 6.7 Å, respectively) were solved along with a supercomplex I+III2 at 7.8 Å resolution. Along side we also determined the first nearly complete atomic structure of isolated mitochondrial complex I at 3.9 Å resolution. With this structure and the known crystal structures of isolated complex III2 and complex IV all observed density in the respirasome could be attributed to the known 80 subunits of the individual complexes, including 132 transmembrane helices. Together these represent the first complete architectures of the dominant, physiologically relevant state of the electron transport chain. More recently, using a novel preparation of functional mitochondrial supercomplex I+III2 this structure has now been resolved to 4.0 Å resolution with multiple supercomplex classes showing alternate conformation around the quinone binding site of complex I indicative of an active to deactive transition.

Host name: Dr Irina Vetter
Host email: imbevents@uq.edu.au

Seminars | This Week

AIBN Women in Science free public lecture

Date/Time: Tuesday 26th September 2017 18:00

Location: Advanced Engineering Building (Building 49, The University of Queensland St Lucia Campus)

Title of talk: The Importance of Diversity and Inclusive Leadership in Science and Innovation
Speaker's name: Professor Geri Richmond
Speaker's organisation: Presidential Chair in Science and Professor of Chemistry, University of Oregon, Director of COACh
Talk abstract: Solving the complex problems that we face in our world today requires a more talented workforce than we have ever needed before. Such a workforce must be comprised of a wide range of diverse talents and creative insights. No segment of the population can be ignored or overlooked in this talent search. This presentation will describe the most recent research that demonstrates the positive impact that social and informational diversity has on science and innovation, the reasons for this impact and the importance of committed leadership in achieving a strong and inclusive workplace where creativity and productivity is maximized.

Host name: UQ AIBN
Host email: reception@aibn.uq.edu.au

Seminars | This Week

IMB Centre for Inflammation & Disease Research Forum

Date/Time: Friday 29th September 2017 09:00

Location: Large seminar room, QBP (Building 80), UQ St Lucia

Title of talk: Influenza virus immunopathology
Speaker's name: Kirsty Short
Speaker's organisation: UQ

Title of talk: Ex-vivo assessment of innate immune responses in the lung
Speaker's name: Peter Sly
Speaker's organisation: UQ

Host name: A/Prof Kate Schroder
Host email: k.schroder@uq.edu.au

Seminars | This Week

Cell Biology Forum

Date/Time: Wednesday 27th September 2017 09:00

Location: Large Seminar Room

Title of talk: TBA
Speaker's name: Michele Bastiani
Speaker's organisation: IMB, UQ (Parton lab)

Host name: Brett Collins
Host email: b.collins@imb.uq.edu.au

Seminars | This Week

QBI Neuroscience Seminar

Date/Time: Wednesday 27th September 2017 11:00

Location: QBI Auditorium

Title of talk: Neuronal Trafficking - Linking mechanisms to functions in live neurons
Speaker's name: Dr Iris Wang
Speaker's organisation: Queensland Brain Institute
Talk abstract: Neurons are the most polarized cells in human body, with highly specialized dendritic and axonal structures to facilitate the information flow through the brain circuits. A dynamic intracellular vesicle trafficking system enables the efficient material transport underlying complicated neural activities. Here I will share my recent studies using advanced microscopy techniques to explore the neuronal trafficking in axons and postsynaptic dendritic spines of live neurons.

Host name: Deirdre Wilson
Host email: d.wilson@qbi.uq.edu.au

Seminars | This Week

Genomics of Development and Disease Division Seminar Series

Date/Time: Thursday 28th September 2017 11:00

Location: IMB Large Seminar Room, Level 3

Title of talk: The role of SOX7 transcription factor in early blood vessel development
Speaker's name: Ivy Chiang
Speaker's organisation: Francois Lab

Title of talk: The puzzle of sex and its missing pieces
Speaker's name: Liang Zhao
Speaker's organisation: Koopman Lab

Other Details: Proudly sponsored by Jenny Peters of Integrated Sciences

Host name: Christelle Adolphe
Host email: c.adolphe@uq.edu.au

Seminars | This Week

AIBN Seminar Series

Date/Time: Friday 29th September 2017 12:00

Location: Level 4 Building 75

Title of talk: Microtechnologies For Controlling And Probing Multicellular Interaction Heterogeneity In Human Diseases
Speaker's name: Professor Yi-Chin Toh
Speaker's organisation: National University of Singapore
Talk abstract: Under physiological conditions, cells function within a tissue context where they interact with other cells through soluble signaling and cell-cell adhesions. Aberrations in these interactions are known to contribute to various human diseases, most notable being cancer and developmental disorders. Current technologies for studying cell-cell interaction heterogeneity are still limited by the consistency and throughput in which they can control cellular interactions across different length scales, as well as the ability to account for inter-patient variability. I will present micropatterning and microfluidic technologies designed to understand how changes in inter-cellular interactions are manifested in stem cell differentiation fates and drug responses. I will illustrate the use of micropatterned human pluripotent stem cells (hPSCs) to generate cell adhesion-mediated mechanical gradients, which in turn can spatially direct neural differentiation for form organized 3D neuroepithelium (NE) structures. These 3D micropatterned NE structures can be related to early neural tube development and are sensitive to drugs that cause a class of human birth defects known as neural tube defects (NTD), demonstrating their utility as a developmental disease model. In the context of cancer, we have developed Patient-Derived Micro-Avatar Chips (PD-MAC), which integrate the biological diverse characteristics of patient-derived tumor cells and the high configurability of microfluidic systems, to study tumor-environment interactions at the cellular and systemic level. A 3D microenvironment can be engineered using micro-structures to support the formation and remodeling of patient-derived parental and metastatic oral squamous cell carcinoma (OSCC) into 3D micro-tumors (PD-mTs). We have developed a modular approach to achieve system integration with various microfluidic components, such as micro-pumps, valves, and a second tissue chip to facilitate the scaling of the PD-MAC to study systemic effects of chemotherapeutic drugs. Finally, we demonstrate the manipulation of parental and metastatic OSCC tumor and immune (NK) cells using hydrodynamic trapping arrays to investigate differential immune-mediated cytotoxicity

Host name: Prof Justin-Cooper White
Host phone number: 63877
Host email: reception@aibn.uq.edu.au

Seminars | This Week

IMB Seminar Series

Date/Time: Friday 6th October 2017 12:30

Location: QBP Auditorium, Bld 80

Title of talk: Sodium channel regulation of sensory modalities
Speaker's name: Associate Professor Frank Bosmans
Speaker's organisation: Johns Hopkins University
Talk abstract: The somatosensory nervous system perceives and transfers sensory modalities such as pain, itch, and temperature from the periphery to the central nervous system. Voltage-gated sodium (Nav) channels are vital for action potential generation, and are key players in this signal transmission process. Recent discoveries identified new roles for particular Nav channel subtypes in pain and other modalities. First, we will discuss how a spider toxin revealed a role for Nav1.1-expressing fibers in eliciting profound hypersensitivity to mechanical stimuli. In the gut, high-threshold mechanosensitive fibers also express Nav1.1 and possess enhanced toxin sensitivity in a mouse model of chronic visceral hypersensitivity. A small-molecule compound that inhibits Nav1.1 activity now shows promise as a drug candidate for mechanical pain and irritable bowel syndrome.
Accumulating evidence suggests a prominent role for Nav1.9 in nociception. Challenges in expressing this channel in a heterologous system and a poor understanding of its tissue distribution complicate the formation of a hypothesis about the role of Nav1.9 in transmitting sensory modalities. To overcome these obstacles, we developed a Nav1.9 stable cell line and generated an EGFP-tagged Nav1.9 mouse line, which allows us to refine tissue distribution and function of this channel in particular cell types. Moreover, Nav1.9-/- mouse behavior reveals a role for this particular subtype in regulating sensory modalities other than pain. We are currently exploring the neuronal circuitry underlying these observations.

Host name: Professor Glenn King
Host email: imbevents@uq.edu.au