Seminars | This Week

CASB

Date/Time: Thursday 19th July 2018 12:30

Location: Large seminar room

Title of talk: Studies of the trimeric disulfide isomerase PmScsC and its redox partner PmScsBα
Speaker's name: Emily Furlong
Speaker's organisation: Institute for Molecular Bioscience
Talk abstract: Bacterial disulfide isomerases are typically dimeric, thioredoxin-fold proteins whose disulfide shuffling activity is essential for the correct folding of many proteins. Throughout the isomerisation process, the catalytic cysteines can become oxidised, inactivating the isomerase and so they rely on a redox partner protein to reduce them back to their active state. Proteus mirabilis Suppressor of copper sensitivity protein C (PmScsC) is a disulfide isomerase that surprisingly, functions as a trimer. We have solved the crystal structure of PmScsC in three different conformations, suggesting that this isomerase has a large range of motion. We have also shown that the periplasmic N-terminal domain of the membrane protein PmScsB (PmScsBα) is the redox partner of this highly dynamic disulfide isomerase. We solved the high-resolution crystal structure of PmScsBα revealing that it comprises two structurally similar immunoglobulin-like folds and modeled the PmScsC:PmScsBα complex using data obtained from small angle neutron scattering with contrast matching. These findings add to our understanding of the poorly characterised Scs proteins and the process of disulfide bond isomerisation in bacterial pathogens.

Host name: Emily Furlong
Host email: e.furlong@uq.edu.au

Seminars | This Week

Winter Course in Advanced Immunology

Date/Time: Monday 16th July 2018 12:45

Location: Translational Research Institute (TRI): Room 2003

Title of talk: MAIT cell-mediated protection and vaccination against pathogenic bacteria
Speaker's name: Dr Alexandra Corbett
Speaker's organisation: Doherty Institute

Host name: Ray Steptoe
Host email: r.steptoe@uq.edu.au

Seminars | This Week

Winter Course in Advanced Immunology

Date/Time: Tuesday 17th July 2018 12:30

Location: Translational Research Institute (TRI): Room 2003

Title of talk: Mass cytometric analysis of life and death decisions in cancer cells
Speaker's name: Dr Daniel Gray
Speaker's organisation: Walter and Eliza Hall Institute

Host name: Ray Steptoe
Host email: r.steptoe@uq.edu.au

Seminars | This Week

QAAFI Science Seminar

Date/Time: Tuesday 17th July 2018 12:00

Location: 3.142, Level 3, QBP Building 80

Title of talk: Advances in avocado rootstock research in Chile
Speaker's name: Prof Mónica Castro Valdebenito
Speaker's organisation: Pontifical Catholic University of Valparaíso
Talk abstract: Avocado's consumption over the past few years has seen an important increase worldwide. More and more people are taking advantages of the many benefits this fruit has. Chile does not stay behind, having the second place of consumption per person worldwide, which reaches 7 kilos annually per capita.
In Chile this specie is cultivated in the central zone of the country, having now almost 30.000 hectares planted. In this zone, there are several limiting conditions for its culture. To name a few, we have problems with replant disease, root asphyxia, salinity (especially sodium chloride) in both soil and irrigation water, among others.

On the other hand, in Chile traditionally the main commercial propagation system used is the grafting on seedling rootstocks. This system produces high heterogeneity in the nursery plants, which causes high variability also in orchards, specially on those located on hillsides. As a solution to this problem, clonal rootstocks of avocado emerges as an alternative for Chile.

Several trials developed by the staff of the Propagation Laboratory of Agronomy school from the Pontificia Universidad Católica de Valparaiso-Chile, showed that the clonal rootstock under the Chilean conditions allowed to increase the productivity between 20 to 60 % additional and the fruit size for exporting quality in 20%. Also, the clonal rootstock allowed to reduce alternative bearing index.

Host name: QAAFI Communications
Host email: qaaficomms@uq.edu.au

Seminars | This Week

Cell Biology Forum

Date/Time: Wednesday 18th July 2018 09:00

Location: Large Seminar Room

Title of talk: TBA
Speaker's name: Rachel Gormal
Speaker's organisation: QBI (Meunier lab)

Host name: Brett Collins
Host email: b.collins@imb.uq.edu.au

Seminars | This Week

Cell Biology Forum

Date/Time: Wednesday 25th July 2018 09:00

Location: Large Seminar Room

Title of talk: TBA
Speaker's name: Yepin Wu
Speaker's organisation: IMB (Parton lab)

Host name: Brett Collins
Host email: b.collins@imb.uq.edu.au

Seminars | This Week

QBI Neuroscience Seminar

Date/Time: Wednesday 18th July 2018 16:00

Location: QBI, Level 7 Auditorium

Title of talk: Microglia, Maleness and Marijuana: How Endocannabinoids Sculpt Brain Sex Differences
Speaker's name: Professor Margaret McCarthy
Speaker's organisation: School of Medicine University of Maryland, Baltimore MD 21230, USA
Talk abstract: Sex differences in the brain are established early in development and generate lasting changes in brain and behavior. Sexual differentiation of the amygdala is responsible for producing a highly conserved sex difference in juvenile rough-and-tumble play behavior. Microglia, the resident immune cells of the brain, actively shape the sexual differentiation of the amygdala by engulfing and phagocytosing newborn cells destined to become astrocytes. Perinatal androgens in males increase endocannabinoid tone, which in turn increases the percentage of phagocytic microglia during the first few days of postnatal life. Ultimately, masculinization of social play by androgens is dependent upon endocannabinoid signaling during a brief developmental window, and microglial control of astrocyte number is critical to establishing the neural circuitry of this complex social behavior.

Host name: Deirdre Wilson
Host email: d.wilson5@uq.edu.au

Seminars | This Week

Genomics of Development and Disease (GDD) Seminar Series

Date/Time: Thursday 19th July 2018 11:00

Location: Large Seminar Room

Title of talk: Real-time finishing bacterial genomes with nanopore sequencing
Speaker's name: Hoang Son Nguyen
Speaker's organisation: IMB, Coin Group

Title of talk: Can human papillomavirus cause skin cancer? Detection of HPV viral transcription in epidermis at single cell resolution
Speaker's name: Samuel Lukowski
Speaker's organisation: IMB-TRI, Coin and Frazer Groups

Other Details: Kindly sponsored by Hilda Troskie from Qiagen

Host name: Quan Nguyen
Host email: quan.nguyen@imb.uq.edu.au