Seminars | This Week

Biological Sciences Seminars

Date/Time: Friday 7th October 2016 15:00

Location: Goddard Building, Room 139

Title of talk: Molecular networks controlling seasonal flowering of wheat
Speaker's name: Ben Trevaskis
Speaker's organisation: CSIRO
Talk abstract: Molecular networks controlling seasonal flowering of wheat

Other Details: If you would like to meet with the speaker, please contact the host

Host name: Milos Tanurdzic
Host email: m.tanurdzic@uq.edu.au

Seminars | This Week

ANZSCDB

Date/Time: Friday 30th September 2016 08:00

Location: Institute for Molecular Biosciences The University of Queensland

Title of talk: 7th Brisbane Cell and Developmental Biology Meeting and the 5th CADD Symposium
Speaker's name: Various
Speaker's organisation: Various

Other Details: Abstract Submission is OPEN NOW & closes FRIDAY, 2nd September

To register & submit your abstract please visit:
http://anzscdb.imb.uq.edu.au/index.php

Postdocs and students will be selected from abstracts to present a 15 min talk:
PRIZES WILL BE AWARDED TO THE BEST TALKS AND POSTERS

Host name: Guillermo Gomez
Host email: g.gomez@imb.uq.edu.au

Seminars | This Week

Biochemistry Alumni Lecture

Date/Time: Wednesday 5th October 2016 12:00

Location: AIBN Seminar Room (ground floor)

Title of talk: Reconstructing ancient proteins: mechanisms for the evolution of protein structure and function
Speaker's name: Professor Joseph Thornton
Speaker's organisation: University of Chicago

Other Details: Lunch will be served following the presentation
This event is free.

RSVP:

Please register online by COB Wednesday 28th September, 2016

Host name: Caroline Esera
Host email: c.esera@uq.edu.au

Seminars | This Week

Cell Biology Forum

Date/Time: Wednesday 28th September 2016 09:00

Location: QBP Large Seminar Room

Title of talk: TBA
Speaker's name: Antje Blumenthal
Speaker's organisation: UQ Diamantina

Host name: Brett Collins
Host email: b.collins@imb.uq.edu.au

Seminars | This Week

CAI Seminar series

Date/Time: Tuesday 27th September 2016 09:30

Location: CAI Seminar room, Centre for Advanced Imaging Bldng 57

Title of talk: Improving Treatments For Newborn Hypoxic-Ischemic Injury And Seizures.
Speaker's name: Dr Tracey Bjorkman
Speaker's organisation: UQ Centre for Clinical Research
Talk abstract: Of the 300,000 babies born in Australia each year most experience a happy and healthy entry to the world. However for a small few complications can arise during birth, often with very little warning and with devastating consequences. Perinatal asphyxia - when the brain is starved of oxygen and blood around the time of birth - is the third leading cause of infant death in Australia and the leading cause of neonatal seizures in newborn babies around the world.
Neonatal seizures are among the most prominent and distinctive signs of serious neurological illness. Of the babies who survive, many will face life-long challenges of physical and mental disability including epilepsy and cerebral palsy. The current antiepileptic drugs used to treat neonatal seizures, most notably phenobarbitone, are relatively ineffective and may cause serious side effects. Despite this, existing treatments for neonatal seizures have changed little over the last 50 years.

Host name: Lorine WIlkinson
Host email: l.wilkinson@uq.edu.au

Seminars | This Week

CAI Special Seminar

Date/Time: Tuesday 27th September 2016 14:00

Location: CAI Seminar room, Centre for Advanced Imaging Bldng 57

Title of talk: Measuring the density of synapses in people using the PET Tracer [11C]UCB-J.
Speaker's name: Henrik Klitgaard
Speaker's organisation: UCB
Talk abstract: http://cen.acs.org/articles/94/i30/New-radiotracer-allows-scientists-count.html?utm_source=Newsletter&utm_medium=Newsletter&utm_campaign=CEN

Host name: Lorine WIlkinson
Host email: l.wilkinson@uq.edu.au

Seminars | This Week

QAAFI Science Seminar Series

Date/Time: Tuesday 27th September 2016 12:00

Location: Large Seminar Room (3.142), Level 3

Title of talk: Bioinformatic and molecular approaches to understand resistance against extracellular pathogens
Speaker's name: Dr Henrik Stotz
Speaker's organisation: The University of Hertfordshire
Talk abstract: Extracellular pathogens, which colonise the apoplast of host plants, cause severe global epidemics, including phoma stem cancer (Leptosphaeria maculans) of oilseed rape, barley leaf blotch (Rhynchosporium commune) and wheat septoria leaf blotch (Zymoseptoria tritici). R gene-mediated effector-triggered defence (ETD) or quantitative (likely multigenic) resistance contribute to protection against these pathogens (Stotz et al., 2014). Bioinformatic approaches are used to identify R gene candidates in the Brassica napus genome and assist in breeding for resistance. Computational models of leucine-rich repeat (LRR) domains are generated to better understand direct interactions between receptors encoded by R genes and their corresponding pathogen effectors. Temporal and spatial distributions of allele frequencies of L. maculans effector genes are studied in relation to R gene deployment in B. napus cultivars to better understand the emergence of stem canker epidemics in Australia. Work at these different scales will enable new approaches to combat emergence and spread of epidemics caused by extracellular pathogens.

Host name: Hannah Hardy
Host email: h.hardy@uq.edu.au

Seminars | This Week

School of Biomedical Sciences

Date/Time: Thursday 29th September 2016 15:00

Location: 42-216, Prentice Blg, St Lucia

Title of talk: From Jesse James to the Berdella serial homicides: Lessons Learned from 47 years of Forensic Anthropology Consulting in Kansas
Speaker's name: Dr Michael Finnegan
Speaker's organisation: Kansas State University, US
Talk abstract: Forensics expert Dr Michael Finnegan is to speak on high-profile US crimes

Host name: Dr Carl Stephan
Host phone number: +61 7 3365 7485
Host email: c.stephan@uq.edu.au

Seminars | This Week

CASB Seminar Series

Date/Time: Wednesday 28th September 2016 16:00

Location: Large Seminar Room 3.143

Title of talk: Less is more: Using sparse matrix substrate libraries to produce potent and selective protease inhibitors
Speaker's name: Associate Professor Jonathan Harris
Speaker's organisation: IHBI-QUT
Talk abstract: Proteases occupy a privileged position in living systems as a result of their irreversible cleavage of substrates. Consistent with this they have an ability to act as one way switches in signal transduction pathways making them ideal targets for therapeutic intervention. Therapeutic protease inhibitors have historically been discovered through screening of large natural product libraries and synthetic libraries, through engineering of existing inhibitors or through the use of combinatorial, randomised positional-scanning libraries to identify substrate-like motifs that can be modified to produce inhibitors. We have adapted the last strategy and used a focused, non-combinatorial approach to develop small, sparse matrix substrate libraries to provide fine mapping of a protease's active site. Because the sparse matrix library is composed of individually synthesised substrates, it over comes a major disadvantage of traditional positional scanning peptide libraries which are unable to assess positional cooperativity effects in a sequence due to decoupling of adjacent amino acids during combinatorial synthesis. Using the sparse matrix approach we have been able to synthesise high efficiency substrates for the kallikrein proteases KLK4, 5, 7 14; plasmin; matriptase-2; human neutrophil elastase and myeloblastin. In turn information from these substrates has been used to guide design of transition state and bioscaffolded inhibitors with low nanomolar to picomolar inhibitory potencies and in some cases hundred fold selectivity against closely related proteases.

Host name: Joakim Swedberg
Host email: j.swedberg@imb.uq.edu.au